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CombiLac^®

功能型药用辅料CombiLac® 是基于乳糖的专门设计用于直接压片的共加工物。它含有70%的alpha一水乳糖，20%的微晶纤维素和10%的玉米淀粉，各组分均符合Ph.Eur., USP-NF, 和JP 药典要求. 三种成分紧密均匀的结合为一体。CombiLac® 拥有超越同样组成的物料混合物，可以制成高质量的片。它的快速崩解不依赖于片硬，可以有效地改善药物的溶出释放。杰出的流动性也保证了一致的片重，适用于直接压片。

Shelf life / Retest:
24 months

Standard Packaging:
20 kg - Carton box with PE-EVOH-PE Inliner

粒度分布
[Air jet sieving]

< 32 µm: NMT 15%
< 160 µm: 35 - 65%
< 250 µm: NLT 85%

典型值

堆密度 [g/l]: 450
振实密度 [g/l]: 540
安息角: 30 °
豪森指数 1.19
卡尔指数： 16 %

MCC Starch Lactose_Tablet hardness_low friability_sticking picking_fast disintegration_direct compression

好处

杰出的流动性
优秀的可压性
快速，不依赖于硬度的崩解改善药物的溶解释放
低脆碎度
利用协同作用，最大程度的避免了单个填充剂功能的局限性

用途

直接压片
口服固体制剂
干法制粒压片

典型粒径分布something new

EXCiPACT Certificate

Shelf life - Retest Date

Sustainability Statement

Sustainability Whitepaper

14001_eng_2016-2018.pdf

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