MEGGLE Excipients | Case Study with Captopril: Overcome Challenges of Elastic Deformation with the Right Excipient

CASE STUDY WITH CAPTOPRIL

Overcome Challenges of Elastic Deformation with the Right Excipient

Abstract:

Developing a medicine in which the active ingredient has elastic deformation is always challenging, as elastic forces affect the compression capacity of the formulation, resulting in tablets with capping, low tablet breaking force and high friability. Finding an ideal formulation with excipients that can mask the effects of elastic deformation is part of obtaining a tablet with good tablet properties so that the manufacturing process has quality and robustness.

Among the active ingredients that have elastic deformation is Captopril, an antihypertensive, sold in solid pharmaceutical form. Conventional Captopril formulations are often unable to mask the effects of elastic deformation, which can cause significant implications during production and also on the effectiveness of the medicine.

Objective:

This study aims to present the obstacles encountered in conventional Captopril formulations and highlight how lactose-based technological excipients can promote improvement and scaling more effective and
robust.

Authors:

Many thanks to the authors for this exciting case study.

Guilherme Brandão1 & Gabrielli Vitória da Cunha1
1 MEGGLE Excipientes do Brasil Ltda

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MEGGLE Experts in Excipients

CaseStudyCaptopril