The role of mechanical properties in DPI carriers

MEGGLE Excipients and the University of Kiel have joined forces to shed light on this interesting topic. 

Introduction:

• Aerodynamic performance of interactive blends depends on mixing time/energy
• Leading hypothesis assumes the effect of so called press-on-forces (i.e deformation of particles during mixing)
• Mechanical properties of particles should predict the behaviour of fine particle fraction (FPF) with respect to mixing time if the hypothesis holds true

Aim:

Verify the relationship between mechanical properties and FPF

1. Create model carriers with varying plasticity
2. Evaluate their mechanical properties
3. Investigate aerodynamic performance
4. Link mechanical properties and aerodynamic performance

Authors:

Many thanks to the authors for this exciting publication.

Zeredescht Majid¹, Ricarda Leister^², Constanze Mueller^², Regina Scherließ¹
1 Department of Pharmaceutics and Biopharmaceutics, Kiel University, Gutenbergstr. 76, 24118 Kiel, Germany
2 Meggle GmbH & Co.KG, Megglestr. 6-12, 83512 Wasserburg am Inn, Germany

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